The Mangosteen Peel Ethyl Acetate Extract-based Cream Inhibits Ultraviolet-B Radiation-induced Hyperpigmentation in Guinea Pig Skin

BACKGROUND: Ultraviolet B (UVB) radiation is the main factor causing aberrant melanin pigments leading to skin hyperpigmentation. Retinoic acid and hydroquinone are primary preference for whitening agents in preventing However, these treatments could induce slight-to-severe irritation cancer. Mangosteen peel possesses α-mangostin, constituent of xanthones mangosteen that has potency as an anti-tyrosinase treating issues AIM: This study aims demonstrate capacity ethyl acetate extract-based cream inhibiting UVB radiation-induced hyperpigmentation guinea pig. MATERIALS AND METHODS: A total 25 female pigs were used produce UVB-irradiated model. Guinea pig skins treated with 12% cream. Mushroom tyrosinase inhibitor activity was evaluate extract vitro. The index after analyzed using a mexameter. percentage epidermal melanin-contained keratinocytes tissues masson fontana. Pmel17 expression cell surface determined immunohistochemistry. level tissue homogenates Enzyme-linked immunosorbent assays. RESULTS: showed potent inhibitory against mushroom tyrosinase. Its-based decreased index, melanin, expression, tissues. CONCLUSION: Overall, our demonstrates